New delivery strategy may improve chemotherapy for acute myeloid leukemia

CNL augments the efficacy of cytarabine/venetoclax treatment in in vivo AML models. (A–C) Bioluminescence images (A), their quantification (B) and survival of MOLM-13 Luc-YFP bearing NRG mice (C) treated for 12 days with control or CNL (30 mg/kg; intravenous; every other day), Ara-C (25 mg/kg; intraperitoneally), and venetoclax (100 mg/kg; oral gavage) both 5 days on/2 days off then 5 days on again alone or in combination. N = 5/group. B: *p The FASEB Journal (2022). DOI: 10.1096/fj.202200765R

Many drug-resistant tumors have dysfunctional metabolism of ceramide, a metabolite that promotes cell death.

Investigators who previously demonstrated that augmenting ceramide can counter tumors’ drug resistance mechanisms have now shown that adding ceramide nanoliposomes can improve the efficacy of a standard chemotherapy regimen of venetoclax plus cytarabine in models of acute myeloid leukemia.

In their study published in The FASEB Journal, the researchers also uncovered several mechanisms behind these effects.

“Ceramide-based therapeutics had been a decades long passion for senior author Dr. Mark Kester, who sadly passed away this summer, and we will continue his legacy to assess the utility of the ceramide nanoliposome in the clinic. This publication is part of the basis for testing the potential of the ceramide nanoliposome in , which are expected to begin in 2023,” said corresponding author Todd Fox, Ph.D., of the University of Virginia.

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More information:
Andrei V. Khokhlatchev et al, Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia, The FASEB Journal (2022). DOI: 10.1096/fj.202200765R

New delivery strategy may improve chemotherapy for acute myeloid leukemia (2022, September 21)
retrieved 21 September 2022

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